Manchester United has been drawn against Barcelona in the Europa League knockout stage play-offs.
The eight teams that finished third in their Champions League groups will face the eight runners-up from their Europa League groups, including United.
Juventus will play Nantes, and Jose Mourinho’s Roma team will play FC Salzburg.
On February 16 are the first legs, and on February 23 are the second legs.
Arsenal qualified for the last 16 as one of the winners when they won their Europa League group.
United, who placed second in their group behind Real Sociedad, will travel for the first game at the Nou Camp, with the return match taking place at Old Trafford seven days later.
Erik ten Hag’s side were heavily linked with Barcelona midfielder Frenkie de Jong during the summer, but the Dutch international ended up staying with the Spanish side.
Barcelona, who are top of La Liga, finished third behind Bayern Munich and Inter Milan in their Champions League group.
“We will have to compete, going to Manchester against a really top rival and an historic side which has grown a lot with the arrival of [Erik] ten Hag,” said Barcelona boss Xavi.
“[They have] great individual players and it is the toughest rival once again in the Europa League.
“It’s a massive challenge for us.”
Sevilla have won the Europa League six times and will take on Dutch side PSV Eindhoven.
Full play-off round draw
Barcelona v Manchester United
Juventus v Nantes
Sporting Lisbon v Midtjylland
Shakhtar Donetsk v Rennes
Ajax v Union Berlin
Bayer Leverkusen v Monaco
Sevilla v PSV Eindhoven
FC Salzburg v Roma