Barcelona were kept off the top of La Liga by another frustrating draw in Valencia.
Barca – now four without a win in the league – fell behind when Gerard Pique made a mess of a clearance and Ezequiel Garay tapped in at the back post.
Messi then swapped passes with Luis Suarez and drilled in from 20 yards to equalise.
But Barca could not find a winner to leave Sevilla top of the table.
Sevilla had earlier picked up their fourth win a row by beating 10-man Celta Vigo 2-1.
In Valencia, Barcelona had 75% of possession but could only muster five shots on target all game, with Messi going closest to a winner when Neto saved his low shot.
Valencia have now drawn six of their eight league games, with Barcelona – brilliant against Tottenham in midweek – without a league win since beating Sociedad last month. (BBC)